2018年10月11日 9:30-11:30

清华大学生物新馆143

报告人

Dr. Patrik Ernfors 

Department of Medical Biochemistry and Biophysics (MBB), Karolinska Institute Stockhom, Sweden

主持人

Dr. Bai Lu

题目

Understanding the nervous system one cell at a time using single-cell RNA sequencing

摘要

  The nervous system is highly complex, containing a multitude of specialized, precisely positioned and interconnected cell types which together create highly refined connectivity patterns that execute complex behaviors. A number of novel technological advances including single cell RNA-sequencing (scRNA-seq), optogenetic modulation and high-resolution 3D imaging pave the way for expanding our understanding of the physiology and pathophysiology of the nervous system with unprecedented detail – one cell at a time. I will discuss our recent advances using scRNA-seq to decipher the molecular taxonomy of nervous system and how the identification of cell types and their transcriptomes open for functional predictions that can be tested in rational experiments to decode how the nervous system works. I will also discuss how these technological advances are applicable to understand transcriptional changes underlying diseases and disorders of the nervous system and furthermore, how they enable for linkage of genomic loci implicated in for example mental disorders onto specific brain cell types, thus opening for identification if discrete cell types are central to disease etiology.

公众号ID: THU_McGovern

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