Volume 1 Issue 2

2023年09月21日

The Innovation Medicine

第一卷第二期正式出版

On the cover

There are over 55 million dementia patients in the world. Among them, Alzheimer's disease (AD) is most commonly seen, which typically causes disability and care-dependence among elderly people. The incidence rate of AD gradually increases with age among middle-aged and elderly people, thus having a particularly severe impact on the aging society. Unfortunately, there is currently no effective method to completely cure AD. Faced with this world-class challenge, global scientists continue to work on the potential pathological mechanisms, diagnosis, and treatment of AD, hoping to make breakthroughs in new biomarkers, imaging diagnosis, and peripheral blood measurement, thereby improving the early diagnosis accuracy of AD and providing more effective targets for new drug development. In the future, medicine will leverage artificial intelligence to further accelerate the pace of breakthroughs in basic research, promote the generation of new therapies, and ultimately win the battle against AD.

Illustrated by Shuyu Hao, Tianbin Song, Haitao Wang, Ji Dai, Ke Zhang, Yuan Huang, Huiyu Xu, Min Shang, Yue Ren, Yuechan Chen, Xinchun Qi, Xiaoyu Lin and Ke Chen.

本期封面主题

阿尔茨海默病（Alzheimer's Disease）。全球有超过5500万的痴呆患者；而阿尔茨海默病（AD）是痴呆最常见的形式；也是造成全球老年人失能和依赖照护的主要原因之一。AD发病率在中老年人中随年龄增长而升高，因此对当今老龄化社会的冲击尤其严重。目前医学科技尚无可以完全治愈AD疾病的有效方法。面对这一世界级难题，全球科学家们在AD的潜在发病机制、早期诊断和治疗方面持续发力。期待未来在新的生物标志物、影像诊断和外周血标志物测定等方面取得新的突破；从而进一步提高AD的早期诊断准确率；并为其新药研发提供更有效的靶点。未来医学科学家将借助人工智能，进一步加速AD基础研究进程，促进AD新疗法的诞生，从而使人类彻底摆脱AD疾病带来的困扰。

1. The Innovation Medicine 简介

The Innovation Medicine（ISSN 2959-8745）是The Innovation的医学姊妹刊，通过开放获取（Open Access）的方式面向全球发表创新、严谨和前沿的重要医学研究进展。The Innovation Medicine由北京大学的乔杰院士担任主编。

2. Event | 事件

2023年2月19日

First Received | 收到第1篇投稿

2023年4月22日

First Accepted | 第1期首篇文章接收

2023年4月28日

MEMO | 战略合作备忘录

The Hong Kong Polytechnic University + The Innovation Medicine

2023年5月6日

First Online | 第1期首篇文章Online

2023年5月26日

MEMO | 战略合作备忘录

The First Affiliated Hospital of Anhui Medical University + The Innovation Medicine

2023年6月21日

First Issue Lives | 第1期全部文章Online

2023年6月28日

Launch the First Issue | 第1期正式出版

2023年8月7日

First Citation | 第一次引用

2023年9月21日

Second Issue | 第2期正式出版

3. Contents | 本期内容

本期内容覆盖主题：AI在医学的应用、阿尔茨海默病、帕金森病、抗体药物、CDK4/6抑制剂、胃肠道癌、呼吸道病毒感染、空气污染与端粒长度、肿瘤边界术中可视化等；共发表15篇文章，包括1篇Editorial，1篇News & Buzz，4篇Commentary，1篇Letter，1篇Illustration，1篇Perspective，2篇Article，1篇Report，和3篇Review。本期作者来自5个国家。

3.1

Editorial

CDK4/6 inhibition: What’s happening beyond CDK4/6 inhibition may also matter

原文链接：https://www.the-innovation.org/article/doi/10.59717/j.xinn-med.2023.100016

DOI: https://doi.org/10.59717/j.xinn-med.2023.100016

3.2

News & Buzz

Where is the boundary of wildfire smoke?

原文链接：https://www.the-innovation.org/article/doi/10.59717/j.xinn-med.2023.100024

DOI: https://doi.org/10.59717/j.xinn-med.2023.100024

3.3

Commentaries

First clinical trial of chronic spinal cord injury treated with a single drug

原文链接：https://www.the-innovation.org/article/doi/10.59717/j.xinn-med.2023.100029

DOI: https://doi.org/10.59717/j.xinn-med.2023.100029

Aberrant stress granule network is involved in CMT2 neuropathies

Universal chimeric antigen receptor-T cells: An opening era for T-cell malignancies

原文链接：https://www.the-innovation.org/article/doi/10.59717/j.xinn-med.2023.100028

DOI: https://doi.org/10.59717/j.xinn-med.2023.100028

Advancing the battle against Alzheimer's Disease: A focus ontargeting tau pathology by antisense oligonucleotide

原文链接：https://www.the-innovation.org/article/doi/10.59717/j.xinn-med.2023.100020

DOI: https://doi.org/10.59717/j.xinn-med.2023.100020

3.4

Letter

ADpred: A non-invasive model for three types of dementia and mild cognitive impairment

原文链接：https://www.the-innovation.org/article/doi/10.59717/j.xinn-med.2023.100026

DOI: https://doi.org/10.59717/j.xinn-med.2023.100026

3.5

Illustration

Fluorescence-guided visualization of pancreatic neuroendocrine tumor borders

原文链接：https://www.the-innovation.org/article/doi/10.59717/j.xinn-med.2023.100025

DOI: https://doi.org/10.59717/j.xinn-med.2023.100025

3.6

Perspective

A new perspective in the research of antibody drug conjugate

原文链接：https://www.the-innovation.org/article/doi/10.59717/j.xinn-med.2023.100018

DOI: https://doi.org/10.59717/j.xinn-med.2023.100018

3.7

Article

Association between air pollution and telomere length: A study of 471,808 UK Biobank participants

Advanced prompting as a catalyst: Empowering large language models in the management of gastrointestinal cancers

原文链接：https://www.the-innovation.org/article/doi/10.59717/j.xinn-med.2023.100019

DOI: https://doi.org/10.59717/j.xinn-med.2023.100019

3.8

Report

Dynamic functional connectivity assesses the progression of Parkinson’s disease

原文链接：https://www.the-innovation.org/article/doi/10.59717/j.xinn-med.2023.100027

DOI: https://doi.org/10.59717/j.xinn-med.2023.100027

3.9

Reviews

Respiratory viral infections in the elderly: From the perspective of the aging immune system

原文链接：https://www.the-innovation.org/article/doi/10.59717/j.xinn-med.2023.100022

DOI: https://doi.org/10.59717/j.xinn-med.2023.100022

Confinement-guided ultrasensitive optical assay with artificial intelligence for disease diagnostics

原文链接：https://www.the-innovation.org/article/doi/10.59717/j.xinn-med.2023.100023

DOI: https://doi.org/10.59717/j.xinn-med.2023.100023

Artificial intelligence for medicine: Progress, challenges, and perspectives

原文链接：https://www.the-innovation.org/article/doi/10.59717/j.xinn-med.2023.100030

DOI: https://doi.org/10.59717/j.xinn-med.2023.100030

4. 投稿指南

期刊主页：

www.the-innovation.org/medicine

投稿网址：

mc03.manuscriptcentral.com/innovation-medicine

作者指南：

www.the-innovation.org/medicine/authors

联系邮箱：

medicine@the-innovation.org

文章类型：

5. Call for Editorial | 诚聘编委

联系邮箱：medicine@the-innovation.org

6. 回顾：The Innovation Medicine首刊微信推送

点击图片查看原文

7. 回顾：The Innovation Medicine首刊Highlights

Video 1 Video Highlights | 视频解读

8. 期刊特色

1. Short processing time from submission to first decision (regular <3 weeks, fast track <1 week).

2. Improve the quality of figure and charts by artists of the Central Academy of Fine Arts.

3.  Promote your paper worldwide.

The Innovation 简介

扫二维码 ｜ 关注期刊官微

The Innovation是一本由青年科学家与Cell Press于2020年共同创办的综合性英文学术期刊：向科学界展示鼓舞人心的跨学科发现，鼓励研究人员专注于科学的本质和自由探索的初心。作者来自全球55个国家；已被136个国家作者引用；每期1/5-1/3通讯作者来自海外。目前有196位编委会成员，来自21个国家；50%编委来自海外；包含1位诺贝尔奖获得者，37位各国院士；领域覆盖全部自然科学。The Innovation已被DOAJ，ADS，Scopus，PubMed，ESCI，INSPEC，EI等数据库收录。2022年影响因子为32.1，CiteScore为23.6。秉承“好文章，多宣传”理念，The Innovation在海内外各平台推广作者文章。

期刊官网：

www.the-innovation.org

www.cell.com/the-innovation

期刊投稿（Submission）：

www.editorialmanager.com/the-innovation

商务合作（Marketing）：

marketing@the-innovation.org

The Innovation 创刊概念片

据说 The Innovation 创刊概念片很炫酷！这里“快递”中英文字幕的视频，一起来练练听力吧！还有概念片创作背后的故事......

点击图片查看原文

Logo｜期刊标识

See the unseen & change the unchanged

创新是一扇门，我们探索未知；  

创新是一道光，我们脑洞大开；  

创新是一本书，我们期待惊喜；  

创新是一个“1”，我们一路同行。

The Innovation 姊妹刊

The Innovation